Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells.

Beschreibung:

Lassen sich Tumoren mit Antihistaminika bekämpfen? Eine aktuelle Studie liefert Hinweise, dass dieser Ansatz durchaus wirksam sein könnte. Lesen Sie mehr:


-Antihistaminika im Tierversuch wirksam gegen Melanome


-Bestimmte Subgruppe der myeloiden Suppressorzellen durch Antihistaminika reduzierbar


Eine Information in deutscher Sprache von Sonja Schmitzer ©2014 DocCheck

"Krebs: Alle Augen auf Antihistaminikum"
.

"Auch dieser Link ist von Interesse:
Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells"

.

Abstract

It has been shown recently that MCs are required for differential regulation of the immune response by granulocytic versus monocytic MDSCs. Granulocytic MDSCs promoted parasite clearance, whereas monocytic MDSCs enhanced tumor progression; both activities were abrogated in MC-deficient mice. Herein, we demonstrate that the lack of MCs also influences MDSC trafficking. Preferential trafficking to the liver was not seen in MC-deficient mice. In addition, evidence that the MC mediator histamine was important in MDSC trafficking and activation is also shown. MDSCs express HR1-3. Blockade of these receptors by HR1 or HR2 antagonists reversed the histamine enhancement of MDSC survival and proliferation observed in cell culture. In addition, histamine differentially influenced Arg1 and iNOS gene expression in MDSCs and greatly enhanced IL-4 and IL-13 message, especially in granulocytic MDSCs. Evidence that histamine influenced activity seen in vitro translated to in vivo when HR1 and HR2 antagonists blocked the effect of MDSCs on parasite expulsion and tumor metastasis. All of these data support the MDSC-mediated promotion of Th2 immunity, leading to the suggestion that allergic-prone individuals would have elevated MDSC levels. This was directly demonstrated by looking at the relative MDSC levels in allergic versus control patients. Monocytic MDSCs trended higher, whereas granulocytic MDSCs were increased significantly in allergic patients. Taken together, our studies indicate that MCs and MC-released histamine are critical for MDSC-mediated immune regulation, and this interaction should be taken into consideration for therapeutic interventions that target MDSCs. © 2014 Society for Leukocyte Biology.



Homepage:



Bewertung der Redaktion:
Der Eintrag wurde von unserer Redaktion mit 5.0 Sternen bzw. als empfehlenswert bewertet (1 Bewertung)!


 Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells.

Rubrik:

Der Eintrag wurde am 01.08.2014 in der Rubrik Medizinische-NEWS eingetragen.


Ändern/Löschen:

Falls Sie den Eintrag zu "Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells." ändern oder löschen wollen, kontaktieren Sie uns bitte per Email mit Angabe der URL "http://reizmageninfo.de/Reizmagen.xml" oder der ID-Nummer "2983".



Europa Apotheek: Ihre Versandapotheke mit den günstigen Medikamenten